3 research outputs found
obophenotype/ncbitaxon: v2023-09-19 Release
What's Changed
Remove outdated CI instructions in README by @cmungall in https://github.com/obophenotype/ncbitaxon/pull/79
20230914 Release by @anitacaron in https://github.com/obophenotype/ncbitaxon/pull/81
Update subset README by @anitacaron in https://github.com/obophenotype/ncbitaxon/pull/82
Add version IRI to taxslim-disjoint-over-in-taxon.owl and not merge taxslim.owl import by @anitacaron in https://github.com/obophenotype/ncbitaxon/pull/84
Download stable NCBI version by @anitacaron in https://github.com/obophenotype/ncbitaxon/pull/85
20230919 Release by @anitacaron in https://github.com/obophenotype/ncbitaxon/pull/86
Full Changelog: https://github.com/obophenotype/ncbitaxon/compare/v2023-06-20...v2023-09-1
Nationwide Experience With Off-Label Use of Interleukin-1 Targeting Treatment in Familial Mediterranean Fever Patients
WOS: 000436403100017PubMed ID: 28992387ObjectiveApproximately 30-45% of patients with familial Mediterranean fever (FMF) have been reported to have attacks despite colchicine treatment. Currently, data on the treatment of colchicine-unresponsive or colchicine-intolerant FMF patients are limited; the most promising alternatives seem to be anti-interleukin-1 (anti-IL-1) agents. Here we report our experience with the off-label use of anti-IL-1 agents in a large group of FMF patients. MethodsIn all, 21 centers from different geographical regions of Turkey were included in the current study. The medical records of all FMF patients who had used anti-IL-1 treatment for at least 6 months were reviewed. ResultsIn total, 172 FMF patients (83 [48%] female, mean age 36.2 years [range 18-68]) were included in the analysis; mean age at symptom onset was 12.6 years (range 1-48), and the mean colchicine dose was 1.7 mg/day (range 0.5-4.0). Of these patients, 151 were treated with anakinra and 21 with canakinumab. Anti-IL-1 treatment was used because of colchicine-resistant disease in 84% and amyloidosis in 12% of subjects. During the mean 19.6 months of treatment (range 6-98), the yearly attack frequency was significantly reduced (from 16.8 to 2.4; P < 0.001), and 42.1% of colchicine-resistant FMF patients were attack free. Serum levels of C-reactive protein, erythrocyte sedimentation rate, and 24-hour urinary protein excretion (5,458.7 mg/24 hours before and 3,557.3 mg/24 hours after) were significantly reduced. ConclusionAnti-IL-1 treatment is an effective alternative for controlling attacks and decreasing proteinuria in colchicine-resistant FMF patients
Nationwide Experience With Off-Label Use of Interleukin-1 Targeting Treatment in Familial Mediterranean Fever Patients
ObjectiveApproximately 30-45\% of patients with familial Mediterranean
fever (FMF) have been reported to have attacks despite colchicine
treatment. Currently, data on the treatment of colchicine-unresponsive
or colchicine-intolerant FMF patients are limited; the most promising
alternatives seem to be anti-interleukin-1 (anti-IL-1) agents. Here we
report our experience with the off-label use of anti-IL-1 agents in a
large group of FMF patients.
MethodsIn all, 21 centers from different geographical regions of Turkey
were included in the current study. The medical records of all FMF
patients who had used anti-IL-1 treatment for at least 6 months were
reviewed.
ResultsIn total, 172 FMF patients (83 {[}48\%] female, mean age 36.2
years {[}range 18-68]) were included in the analysis; mean age at
symptom onset was 12.6 years (range 1-48), and the mean colchicine dose
was 1.7 mg/day (range 0.5-4.0). Of these patients, 151 were treated with
anakinra and 21 with canakinumab. Anti-IL-1 treatment was used because
of colchicine-resistant disease in 84\% and amyloidosis in 12\% of
subjects. During the mean 19.6 months of treatment (range 6-98), the
yearly attack frequency was significantly reduced (from 16.8 to 2.4; P <
0.001), and 42.1\% of colchicine-resistant FMF patients were attack
free. Serum levels of C-reactive protein, erythrocyte sedimentation
rate, and 24-hour urinary protein excretion (5,458.7 mg/24 hours before
and 3,557.3 mg/24 hours after) were significantly reduced.
ConclusionAnti-IL-1 treatment is an effective alternative for
controlling attacks and decreasing proteinuria in colchicine-resistant
FMF patients